RNA molecules can be modified by enzymes through the addition or removal of chemical groups, but the roles of these modifications in the regulation of both mRNAs and non-coding RNAs are not fully ...

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to ...

Researchers have redesigned lipid nanoparticles to make mRNA vaccine delivery more precise, reducing off-target effects.

A tiny chemical modification commonly found on messenger RNAs plays a surprisingly large role in how cells respond to stress, according to a study led by Weill Cornell Medicine investigators. The ...

They are like the architects of our body: messenger ribonucleic acids, or mRNA for short. They contain detailed blueprints for proteins, which are read and translated by their “colleagues”, the ...

CRISPR-Cas13, a powerful RNA-targeting technology is gaining increasing attention as a next-generation gene therapy platform due to its precision and reduced side effects. Utilizing this system, ...

From global vaccines to personalized cancer therapies, mRNA is being considered across several clinical applications, which ultimately creates varying requirements in terms of production scale and ...

A team at UT Southwestern Medical Center has identified a structural trick that lets viruses translate their genetic code inside human cells, even when that code is riddled with “bad” codons the host ...