There are many different ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called ...
This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...
Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In this ...
Image Caption: The factors contributing to R-loop formation. Several factors contribute to R-loop formation, including RNA components, specific DNA structures, histone and RNA modifications, ...
Kyle Miller and his team discovered a potential new target for drug therapies: structures in our DNA called R-loops. A human cancer cell that overexpresses the enzyme APOBEC3B (left) has fewer R-loops ...
New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...
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