The limitations imposed by evolution have implications for AI tools trained on existing sequences and de novo protein design ...

Holly has a degree in Medical Biochemistry from the University of Leicester. Her scientific interests include genomics, personalized medicine, and bioethics.View full profile Holly has a degree in ...

The number of known proteins is infinitely small in comparison to the universe of possible proteins, which could in theory be ...

Large‑scale protein evolution model reveals that common ancestry, not selection or epistasis, is the dominant force limiting ...

A research team has unveiled a breakthrough in understanding how specific genetic sequences, known as pseudogenes, evolve. Rice University's Peter Wolynes and his research team have unveiled a ...

The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has 20 100 possible variants—more combinations than atoms in the observable universe.

Rice University’s Peter Wolynes and his research team have unveiled a breakthrough in understanding how pseudogenes evolve. Led by Wolynes, the D.R. Bullard-Welch Foundation Professor of Science, ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...

Although proteins are composed out of only a small number of distinct amino acids, this deceptive simplicity quickly vanishes when considering the many possible sequences across a protein, not to ...

A research team has revealed the molecular steps that led to the emergence of this plant-specific vacuolar transport system. Their work shows that the acquisition of this pathway was driven by the ...